If you are a Mac user who has experienced issues with hotkey shortcuts not working after using Apple+H to hide Aptana Studio and then restore the application, we've traced this issue to an SWT fragment with the embedded Safari browser.
If you use the standalone Aptana Studio, we will soon be publishing an update to fix this issue.
If you use Aptana as a plug-in to Eclipse (versions older than 3.3.0), follow the instructions below to fix this issue:
http://aptana.com/downloads/org.eclipse.swt.carbon.macosx_3.3.0.v3346.jar
This should also fix this same issue in any other plug-ins that use an embedded browser (e.g. WTP) and also fixes the issue of drag events not working in the embedded Safari, which affects the iPhone preview.